Add like
Add dislike
Add to saved papers

Resting state dynamic functional connectivity in children with Attention Deficit/Hyperactivity Disorder.

Attention Deficit/Hyperactivity Disorder (ADHD) is characterized by inattention, hyperactivity and impulsivity. In this study, we investigated group differences in dynamic functional connectivity between 113 children with inattentive (46 ADHDI) and combined (67 ADHDC) ADHD and 76 typically developing (TD) children using resting state fMRI data. For dynamic connectivity analysis, the data were first decomposed into 100 independent components, among which 88 were classified into eight well-known resting state networks. Three discrete functional connectivity states were then identified using k-means clustering and used to estimate transition probabilities between states in both patient and control groups using a hidden Markov model. Our results showed state-dependent alterations in intra and inter-network connectivity in both ADHD subtypes in comparison with TD. Spending less time than healthy controls in state 1, both ADHDI and ADHDC were characterized with weaker intra-hemispheric connectivity with functional asymmetries. In this state, ADHDI further showed weaker inter-hemispheric connectivity. The patients spent more time in state 2, exhibiting characteristic abnormalities in cortico-subcortical and cortico-cerebellar connectivity. In state 3, a less frequently state observed across the ADHD and TD children, ADHDC was differentiated from ADHDI by significant alterations in functional connectivity between bilateral temporal regions and other brain areas in comparison with TD. Across all three states, several strategic brain regions, mostly bilateral, exhibited significant alterations in both static and dynamic functional connectivity in the ADHD groups compared to TD, including inferior, middle and superior temporal gyri, middle frontal gyri, insula, anterior cingulum cortex, precuneus, calcarine, fusiform, supperior motor area and cerebellum. Our results show distributed abnormalities in static and dynamic functional connectivity between different large-scale resting state networks including cortical and subcortical regions in both ADHD subtypes compared to TD. Our findings show that the dynamic changes in brain functional connectivity can better explain underlying pathophysiology of ADHD such as deficits in visual cognition, attention, memory and emotion processing and cognitive and motor control.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app