Physical Functioning in Heart Failure with Preserved Ejection Fraction: Physical Functioning in HFpEF

Michael F Cosiano, Rachel Tobin, Robert J Mentz, Stephen J Greene
Journal of Cardiac Failure 2021 May 12
Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent, yet interventions and therapies to improve outcomes remain limited. There has been increasing attention towards the impact of comorbidities and physical functioning (PF) on poor clinical outcomes within this population. In this review, we summarize and discuss the literature on PF in HFpEF, its association with clinical and patient-centered outcomes, and future advances in the care of HFpEF with respect to PF. Multiple PF metrics have been demonstrated to provide prognostic value within HFpEF; yet, data are less robust compared with other patient populations, highlighting the need for further investigation. Evaluation and detection of poor PF provides a potential strategy to improve care in HFpEF and future studies are needed to understand if modulating PF improves clinical and/or patient-reported outcomes. Lay Summary.

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