Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis

Erison Santana Dos Santos, Carla Isabelly Rodrigues-Fernandes, Paul M Speight, Syed Ali Khurram, Ibrahim Alsanie, Ana Gabriela Costa Normando, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Luiz Paulo Kowalski, Eliete Neves Silva Guerra, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos-Silva, Adriana Franco Paes Leme
Critical Reviews in Oncology/hematology 2021 May 12, 162: 103352
In numerous types of cancer, the primary tumor site can show a correlation with disease behavior and survival outcomes. In salivary gland tumors (SGTs) this association remains controversial. This study assessed the association between primary sites of SGTs and prognosis. Studies from five databases were assessed and a meta-analysis was performed using studies that presented 95 % confidence interval (95 % CI), hazard ratio (HR) and survival analysis. Gathered information from 46,361 patients showed that site had a prognostic impact on SGTs. Tumors involving minor salivary glands showed worse overall survival (HR = 1.60; 95 % CI = 1.17-2.19; p = 0.003), disease-specific survival (HR=1.63; 95 % CI = 1.12-2.37; p = 0.01), and cause-specific survival (HR=2.10; 95 % CI = 1.72-2.55; p = 0.00001). Tumors from major salivary glands showed better recurrence-free survival (HR=2.31; 95 % CI = 1.77-3.02; p = 0.00001), and locoregional control of disease (HR=2.66; 95 % CI = 1.20-5.91; p = 0.02). Our results showed that the primary site of SGTs has an impact on patient prognosis.

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