Characteristics and Outcomes of Children With Cystic Fibrosis Hospitalized With Cirrhosis in the United States

Christina Thornton, Ranjani Somayaji, Michael Parkins, Mark G Swain, Kathleen J Ramos, Christopher H Goss, Abdel A Shaheen
American Journal of Gastroenterology 2021 April 29

INTRODUCTION: To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States.

METHODS: We conducted a population-based cohort study of hospitalizations among children with CF using the 2016 Kid's Inpatient Database.

RESULTS: In total, 9,615 admissions were analyzed. Diagnosis of cirrhosis was present in 509 (5.3%) and was significantly associated with increased mortality, length of stay, and hospital charges compared with those without cirrhosis. Hepatic encephalopathy was significantly associated with death in children with cirrhosis.

DISCUSSION: Future interventions should be designed to support children with CF who have cirrhosis to improve clinical outcomes.

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