JOURNAL ARTICLE

SGLT-2 inhibition in IgA nephropathy: the new standard-of-care?

Jonathan Barratt, Jürgen Floege
Kidney International 2021 April 17
33878337
Despite supportive measures that slow the rate of progression of chronic kidney disease in IgA nephropathy (IgAN) many patients still progress to end stage kidney disease. Currently employed immunosuppressive strategies lack conclusive efficacy data, while there is evidence for treatment emergent toxicity. A subanalysis of the DAPA-CKD trial, which encompassed 270 patients with a diagnosis of IgAN, now provides early evidence that dapagliflozin may be a safe and effective addition to current standard of care in IgAN.

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