We have located links that may give you full text access.
Potassium bromate (KBrO3) Modulates Oxidative stress and inflammatory biomarkers in NaOH induced crohn's colitis in Wistar rats.
Canadian Journal of Physiology and Pharmacology 2021 April 14
Potassium bromate (KBrO3) present in consumed ozonised water was recently documented to exacerbate experimental gastric ulcer. Report is however vague as regards its effects in the colon; where water reabsorption occurs. In this study, we observed the possible effects of KBrO3 on oxidative stress and inflammatory biomarkers in NaOH induced crohn's colitis. Wistar rats (180-200g) were divided into 6 groups (n=10); 1-control, 2-untreated crohn's colitis (induced by 1.4% NaOH; intra-rectal administration) and 3-6: crohn's colitis treated with vitamin E, KBrO3, vitamin E+KBrO3 and sulphazalazine respectively for seven days. Body weight and stool score were monitored daily. By 3 and 7, excised colon was evaluated for ulcer scores, biochemical and histological analysis. Collected blood samples on days 3 and 7 were assayed for haematological indices using standard methods. Data were subjected to ANOVA and p ≤0.05 considered significant. Platelet/lymphocyte ratio, colonic ulcer score, , malondialdehyde and mast cells were significantly decreased while colonic sulfhydryl, Ca2+ and Na+/K+ ATPase activities were increased following KBrO3 treatment compared with crohn's colitis untreated. Findings suggest that KBrO3 may mitigate against NaOH induced crohn's colitis via inhibiting mast cell population, oxidative and inflammatory content but stimulating colonic sulfhydryl, Ca2+ and Na+/K+ ATPase activities.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app