Serum hs-CRP measured prior transplantation predicts of new-onset diabetes after transplantation in renal transplant recipients

Pham Vu Thuy, Nguyen Thi Thuy Dung, Truong Quy Kien, Nguyen Thi Thu Ha, Nguyen Van Duc, Diem Thi Van, Do Manh Ha, Do Quyet, Tran Viet Tien, Do Nhu Binh, Pham Quoc Toan, Can Van Mao, Le Viet Thang
Transplant Immunology 2021 April 7, : 101392

BACKGROUND: To assess the incidence of new-onset diabetes after transplantation (NODAT) for the first year post-transplantation and the predictive value of high-sensitivity C-reactive Protein (hs-CRP) before transplantation for NODAT prediction in kidney transplantation patients.

MATERIAL AND METHODS: A study of 251 consecutive adult end-stage kidney disease patients transplanted kidneys from living donors, follow-up during the first year to find NODAT. We diagnosed NODAT based on blood glucose or HbA1c following to the criteria of the American Diabetes Association.

RESULTS: The ratio of NODAT was 12.4%. The mean age, mean BMI, the proportion of arteriosclerosis, and the median hs-CRP level in NODAT group were significantly higher than those of non-NODAT group with p < 0.05. Age, BMI and serum hs-CRP had a predictive value for NODAT (Age: AUC = 0.62, p < 0.05, BMI: AUC = 0.626, hs-CRP: AUC = 0.748, p < 0.001).

CONCLUSION: Serum hs-CRP level measured prior transplantation is a good predictor for NODAT in renal transplant recipients.

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