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Safety and efficacy of water pressure endoscopic submucosal dissection for colorectal tumors with submucosal fibrosis (with video).
Gastrointestinal Endoscopy 2021 March 31
BACKGROUND AND AIMS: Colorectal neoplasms with submucosal fibrosis are the most challenging targets of endoscopic resection. Water pressure endoscopic submucosal dissection (WP-ESD) is a recently introduced procedure that has several advantages over conventional endoscopic submucosal dissection (C-ESD). This study aimed to assess the efficacy and safety of WP-ESD for fibrotic colorectal neoplasms.
METHODS: This retrospective observational study investigated 133 colorectal neoplasms expected to have submucosal fibrosis, which were resected by WP-ESD or C-ESD between April 2012 and April 2020. Eighty-seven lesions after endoscopic or surgical treatment, 18 with biopsy scar with fold convergence, and 28 in patients with ulcerative colitis were included. The differences in treatment outcomes, including procedure time and adverse events proportions, between the WP-ESD and C-ESD groups were analyzed. Clinical courses after perforation using WP-ESD were also evaluated, including postprocedural multidetector computed tomography (MDCT) findings obtained immediately after WP-ESD.
RESULTS: Severe submucosal fibrosis was observed in 96 lesions (72.2%). The median procedure time was significantly shorter in the WP-ESD than in the C-ESD group (43.5 minutes [Interquartile range (IQR) 32.8-73] vs 72 minutes [IQR 45-105]; P =.0041). The multivariate analysis revealed WP-ESD as an independent factor for a short procedure time (odds ratio 2.90; 95% confidence interval 1.28-6.55). The proportions of post-ESD electrocoagulation syndrome (PEECS) (11.6% vs 13.1%) and perforation (20.4% vs 22.8%) were similar between the groups. Four of 11 patients with perforation using WP-ESD showed fluid collection on postprocedural MDCT images.
CONCLUSIONS: WP-ESD can shorten procedure time for treating fibrotic colorectal neoplasms.
METHODS: This retrospective observational study investigated 133 colorectal neoplasms expected to have submucosal fibrosis, which were resected by WP-ESD or C-ESD between April 2012 and April 2020. Eighty-seven lesions after endoscopic or surgical treatment, 18 with biopsy scar with fold convergence, and 28 in patients with ulcerative colitis were included. The differences in treatment outcomes, including procedure time and adverse events proportions, between the WP-ESD and C-ESD groups were analyzed. Clinical courses after perforation using WP-ESD were also evaluated, including postprocedural multidetector computed tomography (MDCT) findings obtained immediately after WP-ESD.
RESULTS: Severe submucosal fibrosis was observed in 96 lesions (72.2%). The median procedure time was significantly shorter in the WP-ESD than in the C-ESD group (43.5 minutes [Interquartile range (IQR) 32.8-73] vs 72 minutes [IQR 45-105]; P =.0041). The multivariate analysis revealed WP-ESD as an independent factor for a short procedure time (odds ratio 2.90; 95% confidence interval 1.28-6.55). The proportions of post-ESD electrocoagulation syndrome (PEECS) (11.6% vs 13.1%) and perforation (20.4% vs 22.8%) were similar between the groups. Four of 11 patients with perforation using WP-ESD showed fluid collection on postprocedural MDCT images.
CONCLUSIONS: WP-ESD can shorten procedure time for treating fibrotic colorectal neoplasms.
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