JOURNAL ARTICLE
REVIEW

Post-acute COVID-19 syndrome

Ani Nalbandian, Kartik Sehgal, Aakriti Gupta, Mahesh V Madhavan, Claire McGroder, Jacob S Stevens, Joshua R Cook, Anna S Nordvig, Daniel Shalev, Tejasav S Sehrawat, Neha Ahluwalia, Behnood Bikdeli, Donald Dietz, Caroline Der-Nigoghossian, Nadia Liyanage-Don, Gregg F Rosner, Elana J Bernstein, Sumit Mohan, Akinpelumi A Beckley, David S Seres, Toni K Choueiri, Nir Uriel, John C Ausiello, Domenico Accili, Daniel E Freedberg, Matthew Baldwin, Allan Schwartz, Daniel Brodie, Christine Kim Garcia, Mitchell S V Elkind, Jean M Connors, John P Bilezikian, Donald W Landry, Elaine Y Wan
Nature Medicine 2021 March 22
33753937
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.

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YU-HSIANG WANG

Fantastic review!!

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The Philosopher

Impeccable review!

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Muhammad Hassan Jan

Good

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