JOURNAL ARTICLE

Recurrent hyperhemolytic transfusion reaction in myelodysplastic syndrome- A case based approach

Merline Augustine, Mohandoss Murugesan, Chandran K Nair, Vineetha Raghavan, Sangeetha K Nayanar
Transfusion and Apheresis Science 2021 February 4, : 103073
33581999
We present here a case report of a 27 year old female, with myelodysplatic syndrome suspected to have recurrent hyperhemolytic transfusion reactions (HHTR). Patient was transfusion dependent for ten years and was transfused with leukodepleted and irradiated Packed Red Blood Cells (PRBC). She presented with signs and symptoms of acute intravascular hemolysis, deranged coagulation profile with post transfusion Hb lower than baseline. Post transfusion workup was uneventful. She was managed conservatively with fluid support and methylprednisolone initially. After few uneventful transfusions, patient developed second episode of HHTR with compatible unit.Immunophenotype favored an inflammatory response possibly induced by monocytic lineage. As transfusion dependent, the patient required methylprednisolone as premedication and all subsequent transfusions were uneventful.

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