Will advanced cholangiocarcinoma become a targetable malignancy?

Yara Sarkis, Amine Al Soueidy, Hampig Raphael Kourie
Critical Reviews in Oncology/hematology 2021 January 19, 159: 103233
Cholangiocarcinoma and biliary tract cancers are rare but aggressive tumors that are characterized by an heterogenous molecular and genetic footprint. Genetic aberrations such as FGFR2 fusion and ErBb2 amplification are common in those cancers. Recent studies aimed at exploring the efficacy and benefit of targeted therapy in the treatment of advanced cholangiocarcinoma. Many promising drugs exist and warrant additional investigations. This review will summarize available results and highlight therapeutic strategies incorporated in clinical trials.

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