Enhancing cyst-like lesions of the white matter in tuberous sclerosis complex: a novel neuroradiological finding

Alessandra D'Amico, Teresa Perillo, Carmela Russo, Lorenzo Ugga, Daniela Melis, Claudia Santoro, Giulio Piluso, Giuseppe Cinalli
Neuroradiology 2021 January 22
Tuberous sclerosis complex (TSC) is an autosomal dominant condition clinically presenting with heterogenous clinical features. Multiple neuroradiological manifestations have been associated with TSC, such as tubers, radial migration lines, subependymal nodules, subependymal giant cell astrocytomas, and cyst-like lesions of the white matter (CLLWMs). The latter have been described as non-enhancing well-defined cysts whose pathogenesis is still unknown. We describe 2 TSC patients with CLLWM showing contrast enhancement after Gadolinium injection, a previously unreported entity.

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