Pediatric Acute B-Cell Lymphoblastic Leukemia Developing Following Recent SARS-CoV-2 Infection

Charlotte Leclercq, Fabienne Toutain, Frederic Baleydier, Arnaud G L'Huillier, Noemie Wagner, CĂ©line Lironi, Anne-Marie Calza, Marc Ansari, Geraldine Blanchard-Rohner
Journal of Pediatric Hematology/oncology 2021 January 20
Coronavirus disease-2019 in children has been linked to various clinical presentation, from paucisymptomatic cutaneous eruptions, to multisystemic inflammatory syndrome. We report the case of an 8-year-old boy who presented with persistent fever and pancytopenia, associated to a skin rash. An extensive etiological workup showed a positive serology for severe acute respiratory syndrome coronavirus 2 and Epstein-Barr virus. A few weeks later, type B acute lymphocytic leukemia was diagnosed. This case underlines the polymorphic appearance of coronavirus disease-2019 and the need for critical appraisal.

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