JOURNAL ARTICLE
REVIEW

Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review

Morteza Izadi, Luca Cegolon, Mohammad Javanbakht, Ali Sarafzadeh, Hassan Abolghasemi, Gholamhossein Alishiri, Shi Zhao, Behzad Einollahi, Mandana Kashaki, Nematollah Jonaidi-Jafari, Mosa Asadi, Ramezan Jafari, Saeid Fathi, Hassan Nikoueinejad, Mehrdad Ebrahimi, Sina Imanizadeh, Amir Hosein Ghazale
International Immunopharmacology 2021, 92: 107307
33476982
Severe forms of COVID-19 can evolve into pneumonia, featured by acute respiratory failure due to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In viral diseases, the replication of viruses is seemingly stimulated by an imbalance between pro-oxidant and antioxidant activity as well as by the deprivation of antioxidant mechanisms. In COVID-19 pneumonia, oxidative stress also appears to be highly detrimental to lung tissues. Although inhaling ozone (O3) gas has been shown to be toxic to the lungs, recent evidence suggests that its administration via appropriate routes and at small doses can paradoxically induce an adaptive reaction capable of decreasing the endogenous oxidative stress. Ozone therapy is recommended to counter the disruptive effects of severe COVID-19 on lung tissues, especially if administered in early stages of the disease, thereby preventing the progression to ARDS.

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