JOURNAL ARTICLE
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Behavioral interventions to address rational use of antibiotics in outpatient settings of low-income and lower-middle-income countries.

OBJECTIVES: To explore the current evidence on interventions to influence antibiotic prescribing behavior of health professionals in outpatient settings in low-income and lower-middle-income countries, an underrepresented area in the literature.

METHODS: The systematic review protocol for this study was registered in PROSPERO (CRD42020170504). We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) for studies relating to antibiotic prescribing of health professionals in outpatient settings in low-income and lower-middle-income countries. Behavioral interventions were classified as persuasive, enabling, restrictive, structural, or bundle (mix of different interventions). In total, 3,514 abstracts were screened and 42 studies were selected for full-text review, with 13 studies included in the final narrative synthesis.

RESULTS: Of the 13 included studies, five were conducted in Vietnam, two in Sudan, two in Tanzania, two in India, and two in Kenya. All studies were conducted in the outpatient or ambulatory setting: eight took place in primary health centers, two in private clinics, and three in pharmacies. Our review found that enabling or educational interventions alone may not be sufficient to overcome the ingrained incentives to link revenue generation to sales of antibiotics, and hence, their inappropriate prescription or misuse. Bundle interventions appear to be very effective at changing prescription behavior among healthcare providers, including drug sellers and pharmacists.

CONCLUSIONS: Multi-faceted bundle interventions that combine regulations enforcement with face-to-face education and peer influence may be more effective than educational interventions alone at curbing inappropriate antibiotic use.

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