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The biological characteristics of the canine adenovirus type 1 from fox and the transcriptome analysis of the infected MDCK cell.

Canine adenovirus type 1 (CAdV-1) is the etiologic agent of fox encephalitis, and a virus strain from fox encephalitis is isolated and related researches are conducted. In this experiment, the results showed that the F1301 strain was confirmed to be the CAdV-1. The whole genome of the CAdV-1 F1301 strain isolated from fox was 30535 bp and had higher homology to the other reported CAdV-1 strains. After 0 h, 12 h, and 36 h of CAdV-1 infection, the difference gene of the 592 LncRNA and 11215 mRNA were involved in cell responses to CAdV-1 infection through the PI3K-AKT, Wnt, Herpes simplex, Hepatitis C, and Epstein-Barr virus infection pathway in MDCK. The results indicate that the biological characterization of the CAdV-1 and the MDCK cell-CAdV-1 interaction are clarified. This article is protected by copyright. All rights reserved.

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