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Rhubarb anthraquinone glycosides against cerebral ischaemia-reperfusion injury in rats by regulating brain-gut neurotransmitters.

Rhubarb anthraquinone glycosides (RAGs) have been proven to have significant therapeutic effects on ischaemic stroke, and this effect may be related to the "Microbiome-gut-brain axis". In this study, an HPLC-FLD method was established to measure brain-gut neurotransmitters of rats with cerebral ischaemia-reperfusion injury (CIRI), to explore whether the mechanism of RAGs against CIRI is related to the microbiome-gut-brain axis. A SHIMADZU ODS-3 C18 column was employed for chromatographic separation, and 5-hydroxytryptamine (5-HT), 5-hydroxy indole acetic acid (5-HIAA), glutamic acid (Glu), aspartic acid (Asp), and γ-aminobutyric acid (GABA) were determined simultaneously. The results showed that there is a excellent linear relationship (R2 ≥ 0.9990) and a separation degree in the HPLC-FLD method. And the contents of Asp and Glu in the brain and colon increased (p<0.05), the contents of 5-HT, 5-HIAA, and GABA in the brain and colon decreased (p<0.05) after CIRI. RAGs could effectively reduce the contents of Asp and Glu (p<0.05), and increase the contents of 5-HT, 5-HIAA, GABA in the brain and colon (p<0.05). Combined with the previous experimental results, we can speculate that RAGs can regulate intestinal flora disorder caused by CIRI, and then regulate the imbalance between the release and decomposition of neurotransmitters caused by intestinal flora disorder.

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