Application of microextraction techniques in alternative biological matrices with focus on forensic toxicology: a review

Bruno Ruiz Brandão da Costa, Wilson José Ramos Santos Júnior, Isabela Fernanda Maximiano, Nayna Cândida Gomes, Bruno Toledo Freitas, Bruno Spinosa De Martinis
Bioanalysis 2020 December 16
The interest in alternative biological matrices (e.g., hair and saliva) for forensic toxicology analysis has increased, and recent developments in sample preparation have targeted rapid, cheap, efficient and eco-friendly methods, including microextraction techniques. For this review, we have gathered information about these two hot topics. We discuss the composition, incorporation of analytes and advantages and disadvantages of different biological matrices, and also present the operation principles of the most reported microextraction procedures and their application in forensic toxicology. The outcome of this review may encourage future forensic researches into alternative samples and microextraction techniques.

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