Early Postoperative Magnetic Resonance in the Diagnosis of Persistent Juvenile Angiofibroma

Alberto Schreiber, Marco Ravanelli, Marco Ferrari, Davide Mattavelli, Vittorio Rampinelli, Andrea Bolzoni Villaret, Giacomo Bertazzoni, Michele Tomasoni, Tommaso Gualtieri, Ivan Zorza, Davide Farina, Roberto Maroldi, Piero Nicolai
Laryngoscope 2020 November 27

OBJECTIVES/HYPOTHESIS: Despite improvements in the treatment of juvenile angiofibroma (JA), the rate of persistence (pJA) is still not negligible. In the present study, we assessed the value of early postoperative magnetic resonance imaging (MRI) in depicting unintentional pJAs and designed a MRI-driven decisional flow-chart for pJA management and follow-up.

STUDY DESIGN: Observational study.

METHODS: Patients undergoing early postoperative MRI after endoscopic resection of JA in the Unit of Otorhinolaryngology - ASST Spedali Civili, University of Brescia from 2007 to 2017 were enrolled. MRI was defined as negative or positive based on defined radiological criteria. The diagnostic performance of MRI was evaluated.

RESULTS: The analysis included 26 patients, with a mean age of 16.5 years (range, 11-25). Early MRI was negative for pJA in 21 (80.8%) patients and positive in five (19.2%). No patient with a negative finding was found positive at subsequent follow-up MRIs. The accuracy of a positive finding was confirmed by pathologic examination (three cases) or follow-up MRIs (two cases). The diagnostic performance of MRI was excellent with sensitivity and specificity of 100%. An MRI-driven flow-chart for pJA management and follow-up was designed.

CONCLUSIONS: Early postoperative MRI demonstrated a high diagnostic accuracy in the detection of unintentional pJA. Our MRI-driven strategy and decisional flow-chart could aid in the decision-making process in the management of pJA and definition of postoperative surveillance.

LEVEL OF EVIDENCE: 4 Laryngoscope, 2020.

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