Choosing statins: a review to guide clinical practice

Roberta de Pádua Borges, Nathália Abi Habib Degobi, Marcello Casaccia Bertoluci
Archives of Endocrinology and Metabolism 2020 November 9
Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions. Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios.

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Romeo Mariano

I prefer using only 2 statins:
Pravastatin and Creator.
The reason is that these are the only water soluable statins.
Therefore they are less likely to enter the brain and cause impairment in function (e.g. attention, memory problems).
Realize that half of the dry weight of the brain is cholesterol. And cholesterol is an important signal for the formation of synapses, memory. And it is the building block for neurosteroids.


Aishan Jiang

how to choose statin in clinical practice is the most common problem for the neurologist


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