JOURNAL ARTICLE

Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes

S V Ivanov, R U Ostrovskaya, A V Sorokina, S B Seredenin
Bulletin of Experimental Biology and Medicine 2020 October 24
33098515
Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical analysis showed that the decrease in the number of β cells and a violation of their morphological structure caused by STZ were significantly alleviated by Afobazole administration (10 mg/kg orally for 28 days) to diabetic animals. A correlation between morphometric data and blood glucose level was revealed. A possible role of σ1 -receptors in the cytoprotective effects of Afobazole in respect to pancreatic β cells is discussed.

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