Effect of Type 2 Diabetes Mellitus on Efficacy and Safety of Therapeutic Apheresis for Severe Hypertriglyceridemia

Gulay Simsek Bagir, Okan Sefa Bakiner, Filiz Eksi Haydardedeoglu, Filiz Araz, Melek Eda Ertorer, İlknur Kozanoglu
Therapeutic Apheresis and Dialysis 2020 October 24

INTRODUCTION: The efficacy and safety of triglyceride (TG) apheresis in patients with type 2 diabetes mellitus (DM) is unclear. Diabetic complications may predispose patients to adverse events (AEs) associated with the apheresis procedure, and diabetic dyslipidemia may negatively affect the efficacy of therapeutic apheresis (TA). We investigated the effect of DM on the efficacy and complications of TA.

METHODS: Patients with severe hypertriglyceridemia who underwent apheresis for treatment or for the prevention of acute pancreatitis were included in this retrospective study. Epidemiological data, lipid parameters, and AEs were recorded before and after each therapeutic session.

RESULTS: A total of 166 procedures were performed in 27 patients. Group 1 included 17 patients with type 2 DM, and Group 2 included 10 patients without DM. The mean percentage decrease in TG levels (TG%) was higher in Group 1 (71.9% vs. 60.6%, p < 0.001). The TG% was negatively correlated with the duration of DM in Group 1 (r = -0.49, p < 0.001). The total number of TA sessions was 142 in patients who underwent double filtration plasmapheresis and 24 in patients who underwent therapeutic plasma exchange. We observed 9 (5.4%) mild-to-moderate AEs. No intergroup difference was observed in the total number of AEs (p = 0.06).

CONCLUSION: TA is safe and effective in patients with type 2 DM with severe hypertriglyceridemia. This article is protected by copyright. All rights reserved.

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