Add like
Add dislike
Add to saved papers

Diagnosis of Autism Spectrum Disorder Based on Functional Brain Networks with Deep Learning.

Autism spectrum disorder (ASD) is a neurological and developmental disorder. Traditional diagnosis of ASD is typically performed through the observation of behaviors and interview of a patient. However, these diagnosis methods are time-consuming and can be misleading sometimes. Integrating machine learning algorithms with neuroimages, a diagnosis method, can possibly be established to detect ASD subjects from typical control subjects. In this study, we develop deep learning methods for diagnosis of ASD from functional brain networks constructed with brain functional magnetic resonance imaging (fMRI) data. The entire Autism Brain Imaging Data Exchange 1 (ABIDE 1) data set is utilized to investigate the performance of our proposed methods. First, we construct the brain networks from brain fMRI images and define the raw features based on such brain networks. Second, we employ an autoencoder (AE) to learn the advanced features from the raw features. Third, we train a deep neural network (DNN) with the advanced features, which achieves the classification accuracy of 76.2% and the receiving operating characteristic curve (AUC) of 79.7%. As a comparison, we also apply the same advanced features to train several traditional machine learning algorithms to benchmark the classification performance. Finally, we combine the DNN with the pretrained AE and train it with the raw features, which achieves the classification accuracy of 79.2% and the AUC of 82.4%. These results show that our proposed deep learning methods outperform the state-of-the-art methods.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app