The role of asymptomatic hyperuricemia in the progression of chronic kidney disease CKD and cardiovascular diseases CVD.

In the past decades, questions arose whether hyperuricemia works as an independent risk factor of cardiovascular and renal disease, many evidence cleared this question, that hyperuricemia works as an independent risk factor for chronic kidney disease and cardiovascular diseases. Hyperuricemia defined as an abnormally high level of uric acid. In general, it's defined as serum urate concentration excess of 6.8 mg/dl. Hyperuricemia, which is commonly thought to be just a complication of chronic kidney disease, seems to play a pathogenic role in the progression of renal diseases. In recent years, more attention has been paid to the link between hyperuricemia and chronic kidney disease. Randomized controlled trials have shown that there may be independent associations between hyperuricemia and the progression of cardiovascular and renal morbidity. It is thought to be mediated by renin-angiotensin system activation, nitric oxide syntheses inhibition, and the development of macro and microvascular diseases. Debate continues regarding serum uric acid concentration as an indirect index of renal vascular disease. To sort out the thread, our literature review focus on the role of asymptomatic hyperuricemia in the progress of chronic kidney disease along with the association between hyperuricemia and cardiovascular diseases and a general review of the physiological metabolism of uric acid.