JOURNAL ARTICLE
REVIEW

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Yu-Qiong He, Can-Can Zhou, Lu-Yao Yu, Liang Wang, Jiu-Ling Deng, Yu-Long Tao, Feng Zhang, Wan-Sheng Chen
Pharmacological Research: the Official Journal of the Italian Pharmacological Society 2020 September 29, : 105224
33007416
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) as common life-threatening lung diseases with high mortality rates are mostly associated with acute and severe inflammation in lungs. With increasing in-depth studies of ALI/ARDS, significant breakthroughs have been made, however, there are still no effective pharmacological therapies for treatment of ALI/ARDS. Especially, the novel coronavirus pneumonia (COVID-19) is ravaging the globe, and causes severe respiratory distress syndrome. Therefore, developing new drugs for therapy of ALI/ARDS is in great demand, which might also be helpful for treatment of COVID-19. Natural compounds have always inspired drug development, and numerous natural products have shown potential therapeutic effects on ALI/ARDS. Therefore, this review focuses on the potential therapeutic effects of natural compounds on ALI and the underlying mechanisms. Overall, the review discusses 159 compounds and summarizes more than 400 references to present the protective effects of natural compounds against ALI and the underlying mechanism.

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