LOC389641 promotes papillary thyroid cancer progression by regulating the EMT pathway

Cheng-Ze Chen, Jia-Liang Wen, Bang-Yi Lin, Chen Zheng, Rui-da Quan, Xiao-Hua Zhang, Jin-Miao Qu
Biomarkers in Medicine 2020, 14 (11): 969-980
Aim: Thyroid cancer (TC) is one of the most common types of endocrine malignancy and poses a significant challenge to human health. The long noncoding RNA 389641 ( LOC389641 ) has been found to be associated with many types of cancer. However, the function of LOC389641 in papillary TC (PTC) remains unknown. Our aim is to explore LOC389641 expression and its role in TC. Materials & methods: The function of LOC389641 was determined by colony formation, migration and invasion assays in PTC. Western blot assays were performed to determine the biomarker of epithelial-mesenchymal transition. Results: In this study, we show that LOC389641 is involved in PTC, which suggests that it may be a target for TC therapies.

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