JOURNAL ARTICLE

Control of Cell Migration Using Optogenetics

Leo Valon, Simon de Beco
Methods in Molecular Biology 2021, 2179: 415-425
32939735
Optogenetics uses light to manipulate protein localization or activity from subcellular to supra-cellular level with unprecedented spatiotemporal resolution. We used it to control the activity of the Cdc42 Rho GTPase, a major regulator of actin polymerization and cell polarity. In this chapter, we describe how to trigger and guide cell migration using optogenetics as a way to mimic EMT in an artificial yet highly controllable fashion.

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