Triglyceride-Glucose Index (TyG) is associated with erectile dysfunction : A cross sectional study

Mehmet Yilmaz, Mustafa Karaaslan, Senol Tonyali, Mecit Celik, Tuncay Toprak, Oner Odabas
Andrology 2020 September 16

BACKGROUND: Erectile dysfunction (ED) is often associated with endocrine metabolic diseases such as metabolic syndrome (MetS) and diabetes mellitus (DM), in which insulin resistance (IR) plays a decisive role in pathology. Triglyceride-glucose index (TyG), a simple, inexpensive and easily accessible IR marker, is calculated by fasting serum glucose and triglyceride values.

OBJECTIVES: We aimed to reveal the relationship between TyG index and ED.

MATERIALS AND METHODS: 152 male patients, aged between 24-80 years, admitted to the urology outpatient clinic with complaining erectile insufficiency were evaluated. Liver function tests, complete blood count, fasting serum triglyceride, serum testosterone, fasting glucose, fasting insulin and hemoglobinA1c (HbA1c) were analyzed. TyG index was calculated. All patients were requested to fill in the validated Turkish version of the 5-item International Index of Erectile Function (IIEF-5) survey.

RESULTS: A total of 142 patients were included the study. ED was detected in 91 (64,1%) of the patients. BMI, fasting insulin level, fasting glucose level, IR, GGT, HDL, HbA1c, Triglyceride, TyG, DM, HT and MetS status of the patients in ED group were statistically significantly higher compared to non-ED group (all p < .05). It was found that the cut-off value of TyG index for ED was 8,88 (AUC=0,739, sensitivity 67%, specificity = 68,6%). In multivariate logistic regression analysis, age (OR = 1,07, 95% CI = 1,026-1,115, P = 0,002) and TyG index above 8,88 (OR = 3,865, 95% CI = 1,686-8,859, p = 0,001) were found as independent predictors of ED after accounting for BMI, serum total T and IR.

CONCLUSION: TyG index might be useful in the diagnosis and follow-up of ED.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"