JOURNAL ARTICLE

Association of Clinicopathological Features With Outcome in Chondrosarcomas of the Head and Neck

Sofia Asioli, Poosit Ruengwanichayakun, Matteo Zoli, Federica Guaraldi, Giacomo Sollini, Paolo Greco, Carla Facco, Dino Gibertoni, Brayan Vega Jiménez, Stefania Benini, Mario Turri-Zanoni, Ernesto Pasquini, Diego Mazzatenta, Maria Pia Foschini, Alberto Righi
Otolaryngology—Head and Neck Surgery 2020 September 15, : 194599820957271
32928034

OBJECTIVE: The aim of this study is to assess the association between clinical and radiological features as well as of isocitrate dehydrogenase 1 and 2 ( IDH 1,2) mutations with outcome in head and neck chondrosarcomas.

STUDY DESIGN: Retrospective study.

SETTING: Tertiary referral center.

METHODS: Clinical, histological, and molecular data of patients with head and neck chondrosarcomas treated by surgery were collected.

RESULTS: Forty-six patients were included. The mean age at diagnosis was 56 years (range, 17-78). The tumor originated from the skull base (52.2%), facial bones (28.2%), or laryngotracheal area (19.6%). At last follow-up (median 52.5 months), 38 patients were alive, 30 of which were disease free, whereas 8 had died, 4 of disease progression and 4 of other causes. Fourteen (30.4%) had local recurrence and 2 (4.3%) had lung metastasis. All cases were negative for cytokeratin AE1/AE3, brachyury, and IDH1 at immunohistochemistry, while Sanger sequencing identified IDH1/2 point mutations, typically IDH1 R132C, in 9 (37.5%) tumors arising from the skull base. Margin infiltration on the surgical specimen negatively affected the outcome, whereas no correlation was identified with IDH mutation status.

CONCLUSIONS: An adequate margin positively affects survival. IDH mutation status does not affect patient outcome.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
32928034
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.