Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in Azeri Population of Iran

Mahya Pourostadi, Simin Sattarpour, Behroz Mahdavi Poor, Mohammad Asgharzadeh, Hossein Samadi Kafil, Mehdi Farhoudi, Vahid Asgharzadeh, Ali Vegari, Nima Najafi-Ghalelou, Jalil Rashedi
Endocrine, Metabolic & Immune Disorders Drug Targets 2020 September 10

BACKGROUND: Multiple sclerosis (MS), a disease of central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is way to exert its function.

OBJECTIVE: Possible correlation between vitamin D receptor (VDR) gene and MS was evaluated in Azeri population of Iran.

METHOD: Different genotypes of Bsml site were determined by using PCR-RFLP method in 148 MS patients and 220 nonrelative healthy controls.

RESULTS: In MS patients, genotype bb was significantly higher than the healthy controls (p<0.05). Additionally, most subjects of MS group had been insufficiently exposed to sunlight before the age of 15 (p<0.001). Our findings indicated that the red meat intake in MS patients was significantly higher than the healthy controls (p<0.001). In addition, the healthy controls had appropriate dieting behaviors in comparison to MS patients (excessive intake of some foods) (p=0.0001).

CONCLUSIONS: In conclusion, genotype BB and sufficient exposure to sunlight before the age of 15 were the protective factors against MS. Although, excessive consumption of red meat and inappropriate dieting behaviors were predisposing factors to MS disease.

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