We have located links that may give you full text access.
Association between the progression of IgA nephropathy and a controlled status of hypertension in the first year after diagnosis.
Korean Journal of Internal Medicine 2020 July 32
Background/Aims: Hypertension is considered a risk factor in IgA nephropathy. However, after IgA nephropathy (IgAN) diagnosis, the relationship between early blood pressure control and renal prognosis remains unclear. This study aimed to analyze the association between the prognosis of IgAN patients and a controlled status of hypertension within the first year of IgAN diagnosis.
Methods: We retrospectively analyzed 2,945 patients diagnosed with IgAN by renal biopsy. The patients were divided into 'Normal', 'New-onset', 'Well-controlled' and 'Poorly-controlled' groups using blood pressure data from two consecutive measurements performed within a year. The Kaplan-Meier survival analysis and Cox proportional-hazards regression model were used to survey the independent association between recovery from hypertension and the risk of IgAN progression. The primary endpoint was IgAN progression defined as the initiation of dialysis or kidney transplantation.
Results: Before IgAN diagnosis, 1,239 patients (42.1%) had been diagnosed with hypertension. In the fully adjusted Cox proportional-hazards models, the risk of IgAN progression increased by approximately 1.7-fold for the prevalence of hypertension. In the subgroup analyses, the 'Well-controlled' group showed a statistically significant risk of IgAN progression (Hazard ratio (HR), 3.19; 95% confidence interval (CI), 1.103-9.245; P = 0.032). Moreover, the 'New-onset' and 'Poorly-controlled' groups had an increased risk of IgAN progression compared to the 'Normal' group (HR, 2.58; 95% CI, 1.016-6.545; P = 0.046 and HR, 3.85; CI, 1.541-9.603; P = 0.004, respectively).
Conclusion: Although hypertension was well-controlled in the first year after IgAN diagnosis, it remained a risk factor for IgAN progression.
Methods: We retrospectively analyzed 2,945 patients diagnosed with IgAN by renal biopsy. The patients were divided into 'Normal', 'New-onset', 'Well-controlled' and 'Poorly-controlled' groups using blood pressure data from two consecutive measurements performed within a year. The Kaplan-Meier survival analysis and Cox proportional-hazards regression model were used to survey the independent association between recovery from hypertension and the risk of IgAN progression. The primary endpoint was IgAN progression defined as the initiation of dialysis or kidney transplantation.
Results: Before IgAN diagnosis, 1,239 patients (42.1%) had been diagnosed with hypertension. In the fully adjusted Cox proportional-hazards models, the risk of IgAN progression increased by approximately 1.7-fold for the prevalence of hypertension. In the subgroup analyses, the 'Well-controlled' group showed a statistically significant risk of IgAN progression (Hazard ratio (HR), 3.19; 95% confidence interval (CI), 1.103-9.245; P = 0.032). Moreover, the 'New-onset' and 'Poorly-controlled' groups had an increased risk of IgAN progression compared to the 'Normal' group (HR, 2.58; 95% CI, 1.016-6.545; P = 0.046 and HR, 3.85; CI, 1.541-9.603; P = 0.004, respectively).
Conclusion: Although hypertension was well-controlled in the first year after IgAN diagnosis, it remained a risk factor for IgAN progression.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app