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Caution With the Use of Lopinavir/Ritonavir in Severely Ill Patients for the Treatment of SARS-CoV-2: A Report of Severe Jaundice.

Clementine Levy, Guillaume Lassailly, Erika Parmentier, Thibault Duburcq, Philippe Mathurin, Julien Poissy
American Journal of Gastroenterology 2020 October
INTRODUCTION: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus.

METHODS: This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group.

RESULTS: Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%).

DISCUSSION: Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus.

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