Approaches and Challenges in SARS-CoV-2 Vaccine Development

Gabriel Dagotto, Jingyou Yu, Dan H Barouch
Cell Host & Microbe 2020 September 9, 28 (3): 364-370
The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.

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