JOURNAL ARTICLE

Effects of Trans-Cinnamaldehyde on Reperfused Ischemic Skeletal Muscle and the Relationship to Laminin

Esra Pekoglu, Belgin Buyukakilli, Cagatay Han Turkseven, Ebru Balli, Gulsen Bayrak, Burak Cimen, Senay Balci
Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research 2020 August 5, : 1-10
32752972

PURPOSE: Ischemia-reperfusion (I-R) injury is a serious problem caused by vascular trauma, tourniquet use and/or compartment syndrome. Studies have reported that skeletal muscle function is impaired due to the lower extremity I-R injury. There are insufficient studies on the treatment methods used for the recovery of dysfunction. This study is designed to investigate the effects of trans-cinnamaldehyde (TCA), a volatile oil of cinnamon structure, on the contractile dysfunction due to I-R injury of rat extensor-digitorum-longus (EDL) muscle.

MATERIALS AND METHODS: Sprague-Dawley rats were randomly divided into three groups. Except for the animals in the control group, all animals received saline (3-ml/kg) or TCA solution (30-mg/kg) which was administered orally three times with an 8-h interval before ischemia. After 24-hours, experimental groups were subjected to 3-h of lower extremity ischemia followed by 5-h reperfusion period. Then, the compound muscle action potential (CMAP) and mechanical activity of muscle were recorded using the standard electro-biophysical techniques.

RESULTS: There was a decrease in the maximum contractile force in I-R group compared to the control group ( p  < 0.05). Oxidative damage indicator (MDA) and antioxidant indicator (CAT) increased in the EDL muscle and serum samples in the I-R group ( p  < 0.05). Laminin expression showed a reduction in the I-R group ( p  < 0.05). It was seen that TCA achieve again the maximum contraction force in the EDL muscle ( p  < 0.05) and maintain the expression of laminin ( p  > 0.05).

CONCLUSION: We concluded that TCA has a potential protective effect with antioxidant effects against I-R injury and may maintain laminin levels.

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