Computer Simulation of the Effects of Contrast Protocols on Aortic Signal Intensity on Magnetic Resonance Angiograms

Toru Higaki, Yuko Nakamura, Fuminari Tatsugami, Wataru Fukumoto, Kazuo Awai
Current medical imaging 2020 July 30

BACKGROUND: While iodine-enhanced computed tomography has been studied, detailed information on gadolinium-enhanced magnetic resonance imaging has not been reported.

OBJECTIVE: The purpose of this study was to evaluate the effect of various gadolinium contrast agent (Gd-CA) factors on enhancement on aortic magnetic resonance angiography (MRA) using computer simulation.

METHODS: We developed a computer simulation software combines pharmacokinetic models and tables that converts the blood concentration of particular Gd-CAs into the signal intensity (SI). We simulate aortic time-intensity curves (TIC) on MRA study. We compared the effect of the Gd-CA volume, injection rate, and different Gd-CAs on the TIC.

RESULTS: An increase in the Gd-CA volume from 14.0 to 28.0 ml increased maximal aortic intensity 1.11 times. Changing the injection rate from 1.0 to 2.8 ml/s increased it 1.10 times. Compared with gadoteridol, the maximal signal intensity (SI) of gadoterate-meglumine and gadobutrol was 1.03 and 1.01 times, respectively that of gadoteridol.

CONCLUSION: In our computer-simulated MRA study, different Gd-CA factors resulted in no significant difference in the maximal aortic SI.

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