Islet or pancreas after kidney transplantation: Is the whole still greater than some of its parts?

Jonathan A Fridell, Robert J Stratta
American Journal of Transplantation 2020 August 2
In their landmark publication entitled Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes, Markmann and colleagues report the outcomes of the Clinical Islet Transplantation (CIT) consortium trial 06 of purified human pancreatic islets transplanted into patients with type 1 diabetes following successful kidney transplantation (1). This study was conducted at ten North American transplant centers and demonstrated that in kidney transplant recipients with diabetes on intensive insulin therapy with frequent severe hypoglycemic events and poor glycemic control, islet after kidney (IAK) transplantation can achieve improved glucose homeostasis, normalization of HBA1C levels, and freedom from severe hypoglycemic episodes in 60% of patients at one-year follow-up. In addition, patients reported a significantly improved quality of life even in the presence of insulin resumption.

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