Status of IL-4 and IL-10 driven markers in experimental models of Visceral Leishmaniasis

Srija Moulik, Joyshree Karmakar, Sumit Joshi, Anuradha Dube, Chitra Mandal, Mitali Chatterjee
Parasite Immunology 2020 July 31, : e12783

AIM: Leishmania donovani, the causative agent for visceral leishmaniasis (VL), modulates host monocytes-macrophages to ensure its survival. However, knowledge regarding the host-parasite interactions underpinning the disease remains limited. As disease progression is associated with polarization of monocytes/macrophages towards M2 which is regulated by cytokines IL-4/IL-13 and IL-10, this study evaluated the status of key IL-4 and IL-10 driven markers in experimental models of VL, as also evaluated their correlation, if any, with parasite load.

METHODS: In liver and splenic tissues from L.donovani infected hamsters and BALB/c mice, the parasite burden was determined along with mRNA expression of IL-4 driven markers i.e. CD206, Arginase-I, CCL17, CCL22, PPARγ , STAT-6,KLF-4, FIZZ1 and YM1 along with IL-10 driven markers, CXCL13, IL-10, TGFβ, VDR,CCR2 and CYP27A1.

RESULTS: The mRNA expression of IL-4 and IL-10 driven markers was enhanced in both models, but only in the hamster model, the splenic tissues demonstrated a positive correlation between all the IL-10 driven markers and parasite load.

CONCLUSIONS: Contrary to human VL, both models demonstrated an increased expression of IL-4 and IL-10 driven markers.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"