Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis

Iskandar Tamimi, Arthur Rodríguez González Cortes, Juan-Manuel Sánchez-Siles, Jerome L Ackerman, David González-Quevedo, Ángel García, Farid Yaghoubi, Mohamed Nur Abdullah, Hazem Eimar, Ammar Alsheghri, Marco Laurenti, Ahmad Al-Subaei, Enrique Guerado, David García-de-Quevedo, Faleh Tamimi
Bone 2020 July 27, : 115558

BACKGROUND: Bone strength depends on multiple factors such as bone density, architecture and composition turnover. However, the role these factors play in osteoporotic fractures is not well understood.

PURPOSE: The aim of this study was to analyze trabecular bone architecture, and its crystal and organic composition in humas, by comparing samples taken from patients who had a hip fracture (HF) and individuals with hip osteoarthritis (HOA).

METHODS: The study included 31 HF patients and 42 cases of HOA who underwent joint replacement surgery between 1/1/2013-31/12/2013. Trabecular bone samples were collected from the femoral heads and analyzed using a dual-energy X-ray absorptiometry, micro-CT, and solid-state high-resolution magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectroscopy.

RESULTS: No differences in proton or phosphorus concentration were found between the two groups using 1 H single pulse, 31 P single pulse, 31 P single pulse with proton decoupling NMR spectroscopy, in hydroxyapatite (HA) c-axis or a-axis crystal length. Bone volume fraction (BV/TV), trabecular number (Tb.N), and bone mineral density (BMD) were higher in the HO group than in the HF group [28.6% ± 10.5 vs 20.3% ± 6.6 (p=0.026); ); 2.58 mm-1 ± 1.57 vs 1.5 mm-1 ± 0.79 (p=0.005); and 0.39 g/cm2 ± 0.10 vs. 0.28 g/cm2 ± 0.05 (p=0.002), respectively]. The trabecular separation (Tp.Sp) was lower in the HO group 0.42 mm ± 0.23 compared with the HF group 0.58 mm ± 0.27 (p=0.036). In the HO group, BMD was correlated with BV/TV (r=0.704, p<0.001), BMC (r=0.853, p<0.001), Tb.N (r=0.653, p<0.001), Tb.Sp (-0.561, p<0.001) and 1 H concentration (-0.580, p<0.001) in the HO group. BMD was not correlated with BV/TV, Tb.Sp, Tb.Th, Tb.N, Tb.PF, 1 H concentration or HA crystal size in the HF group.

CONCLUSIONS: Patients with HO who did not sustain previous hip fractures had a higher femoral head BMD, BV/TV, and Tb.N than HF patients. In HO patients, BMD was positively correlated with the BV/TV and Tb.N and negatively correlated with the femoral head organic content and trabecular separation. Interestingly, these correlations were not found in HF patients with relatively lower bone densities. Therefore, osteoporotic patients with similar low bone densities could have significant microstructural differences. No differences were found between the two groups at a HA crystal level.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"