Plasma volume treated with double filtration plasmapheresis and outcomes of acute antibody-mediated rejection in kidney transplant recipients: A retrospective cohort study.

A retrospective cohort study was conducted to evaluate the association between the plasma volume treated by double filtration plasmapheresis (DFPP) and allograft outcomes for the treatment of acute antibody-mediated rejection in kidney transplant recipients. Patients were divided into 2 groups: Group 1, plasma volume treated between 1 and < 1.3 total plasma volume (TPV) and Group 2, plasma volume treated ≥1.3 TPV. Primary outcome was ≥50% reduction of serum creatinine rising from baseline value at 1 month. A total of thirty-two courses (146 sessions) of DFPP were performed; 17 and 15 courses in Group 1 and Group 2, respectively. Primary outcome occurred in 41% of Group 1 and 40% of Group 2 (adjusted risk ratio 1.15 [95%CI, 0.48-2.76]). Graft loss at 1 year did not differ between the two groups (adjusted hazard ratio 0.65 [95%CI, 0.23-1.87]). Infection tendency seemed to be higher in Group 2 (40% vs 18%, P = 0.243). This article is protected by copyright. All rights reserved.