The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review

Wieke W Kremer, Renske D M Steenbergen, Daniëlle A M Heideman, Gemma G Kenter, Chris J L M Meijer
BJOG: An International Journal of Obstetrics and Gynaecology 2020 July 3
This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV positive women to detect cervical cancer and advanced CIN; 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN.

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