We have located links that may give you full text access.
Striatal connectivity in premanifest Huntington disease is differentially affected by disease burden.
European Journal of Neurology 2020 June 31
BACKGROUND: Different amount of cumulative exposure to the toxic mutant form of the huntingtin protein might underlie distinctive pattern of striatal connectivity in premanifest Huntington's disease (pre-HD). Aim of this study is to investigate disease burden-dependent cortical- and subcortical-striatal loops in different pre-HD stages.
METHODS: Sixteen pre-HD participants and 25 controls underwent magnetic resonance exam to investigate striatal structural and functional connectivity. Pre-HD individuals were stratified into far and close to disease onset groups according to the disease-burden score. Cortical-striatal and subcortical-striatal functional connectivity was investigated through seed-ROI and ROI-to-ROI approaches, respectively. Integrity of white matter pathways originating from striatal seeds was investigated through probabilistic tractography.
RESULTS: In far-to-onset pre-HD, the left caudate nucleus showed cortical increased functional connectivity in brain regions overlapping with the default mode network, and increased coupling connectivity with the bilateral thalamus. By contrast, close-to-onset individuals showed increased fractional anisotropy (and mean diffusivity) in the right caudate nucleus and widespread striatal atrophy. Finally, we reported an association between cortical-caudate functional connectivity and caudate structural connectivity, although not surviving multiple comparison correction.
CONCLUSIONS: Functional reorganization of the caudate nucleus might underlie plasticity compensatory mechanisms which recede as premanifest individuals approach clinical symptoms onset and neurodegeneration.
METHODS: Sixteen pre-HD participants and 25 controls underwent magnetic resonance exam to investigate striatal structural and functional connectivity. Pre-HD individuals were stratified into far and close to disease onset groups according to the disease-burden score. Cortical-striatal and subcortical-striatal functional connectivity was investigated through seed-ROI and ROI-to-ROI approaches, respectively. Integrity of white matter pathways originating from striatal seeds was investigated through probabilistic tractography.
RESULTS: In far-to-onset pre-HD, the left caudate nucleus showed cortical increased functional connectivity in brain regions overlapping with the default mode network, and increased coupling connectivity with the bilateral thalamus. By contrast, close-to-onset individuals showed increased fractional anisotropy (and mean diffusivity) in the right caudate nucleus and widespread striatal atrophy. Finally, we reported an association between cortical-caudate functional connectivity and caudate structural connectivity, although not surviving multiple comparison correction.
CONCLUSIONS: Functional reorganization of the caudate nucleus might underlie plasticity compensatory mechanisms which recede as premanifest individuals approach clinical symptoms onset and neurodegeneration.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app