JOURNAL ARTICLE

Phase I trial of docetaxel plus lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 ( 177 Lu-J591) for metastatic castration-resistant prostate cancer

Jaspreet S Batra, Muhammad Junaid Niaz, Young E Whang, Arif Sheikh, Charlene Thomas, Paul Christos, Shankar Vallabhajosula, Yuliya S Jhanwar, Ana M Molina, David M Nanus, Joseph R Osborne, Neil H Bander, Scott T Tagawa
Urologic Oncology 2020 June 27
32600929

BACKGROUND: Docetaxel remains a standard of care for metatsatic castration resistant porstate cancer (mCRPC) and has radiosensitizing properties. The dose limiting toxicity (DLT) of radioimmunotherapy is myelosuppression; dose fractionation of 177 Lu-J591 allows similar administered doses with less toxicity. This study (NCT00916123) was designed to determine the safety, DLT, and maximum tolerated dose of fractionated 177 Lu-J591 administered concurrently with standard docetaxel.

METHODS: Men with progressive mCRPC received docetaxel 75 mg/m2 every 3 weeks with escalating 2 fractionated doses of 177 Lu-J591 (1.48 GBq/m2 up to max of 2.96 GBq/m2 ) with cycle 3. Cycle 4 of docetaxel was planned 6 weeks after cycle 3 to allow for recovery from 177 Lu-J591-associated hematologic toxicity. DLT was defined as delay in docetaxel >3 weeks, prolonged myelosuppression or need for >2 platelet transfusions, febrile neutropenia, or grade ≥3 nonhematological toxicity following 177 Lu-J591. PSA was assessed prior to each cycle and serial computed tomography (CT) and bone scan were performed.

RESULTS: Fifteen men with progressive mCRPC received dose-escalated targeted radionuclide therapy in 4 cohorts up to the highest planned dose (2.96 GBq/m2 ). No DLT was seen at any dose level. Grade 4 neutropenia without fever occurred in 8 (53.5%) and thromboytopenia in 2 (13.3%), with 2 receiving prophylactic platelet transfusion. No grade ≥3 nonhematological toxicity was observed. 11 (73.3%) had >50% PSA decline, with 78.6% having favorable circulating tumor cell counts after 177 Lu-J591. All patients had targeting of known sites of disease by planar 177 Lu-J591 imaging.

CONCLUSION: The combination of 177 Lu-J591 delivered as a single fractionated cycle with docetaxel/prednisone is feasible in patients with mCRPC. Without preselection for prostate-specific membrane antigen, accurate targeting of known sites of disease and a strong preliminary efficacy signal was observed.

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