Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs

Valentine Martlé, Mathias Devreese, Saskia Rauch, Luc Van Ham, Siska Croubels, Valérie Vanhoorne, Chris Vervaet, Sofie Bhatti
Veterinary Journal 2020, 259-260: 105459
The purpose of the present study was to investigate if rectal administration of imepitoin in healthy dogs leads to plasma concentrations comparable to those after oral administration. Significantly lower systemic exposure and maximal plasma concentration (Cmax ) of imepitoin was achieved after rectal compared to oral administration (P≤0.001). Therefore, this study does not support the rectal administration of imepitoin in dogs.

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