Immunology of COVID-19: Current State of the Science

Nicolas Vabret, Graham J Britton, Conor Gruber, Samarth Hegde, Joel Kim, Maria Kuksin, Rachel Levantovsky, Louise Malle, Alvaro Moreira, Matthew D Park, Luisanna Pia, Emma Risson, Miriam Saffern, Bérengère Salomé, Myvizhi Esai Selvan, Matthew P Spindler, Jessica Tan, Verena van der Heide, Jill K Gregory, Konstantina Alexandropoulos, Nina Bhardwaj, Brian D Brown, Benjamin Greenbaum, Zeynep H Gümüş, Dirk Homann, Amir Horowitz, Alice O Kamphorst, Maria A Curotto de Lafaille, Saurabh Mehandru, Miriam Merad, Robert M Samstein
Immunity 2020 June 16, 52 (6): 910-941
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.

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