Add like
Add dislike
Add to saved papers

Comparison of Heart Transplantation Outcomes - Adult Congenital Heart Disease Versus Matched Cardiac Patients in a Quaternary Reference Centre.

BACKGROUND: The number of transplants performed for adult congenital heart disease (ACHD) patients is increasing. We sought to compare survival and post-transplant complications, including graft failure, rejection, dialysis and use of RVAD postoperatively, between ACHD and a cohort of dilated (DCM) and ischemic (ICM) cardiomyopathy patients matched in age and year of transplantation.

METHODS: We retrospectively reviewed our single-institution heart transplant database and selected all patients who had surgery between 1988 and 2017. In our primary analysis, we looked at survival and post-transplant complications across cardiomyopathy groups. Our secondary analysis was matched in order to mitigate era effects as well as differences in age at transplant.

RESULTS: We analyzed a cohort consisting of 303 heart transplant patients with cardiomyopathy due to either 1) ACHD (N=38), 2) ICM (N=110), or 3) DCM (N=155). Kaplan Meier analysis and a multivariable Cox proportional hazard regression model were used for all-cause mortality, and cause-specific hazard regression for cause-specific mortality and morbidity. There was no statistically significant survival difference across groups. The 1-year survival was 68.5% for ACHD, 85.4% for ICM and 85.5% for DCM. By multivariable analysis, ICM and DCM patients showed a 66% relative reduction in risk of death compared to the ACHD group. The matched analysis showed no significant difference in survival across groups.

CONCLUSION: ACHD patients represent a growing high-risk patient cohort referred for transplantation. To improve survival outcomes we need to address modifiable risk factors.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app