We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Angiotensin II inhibits baroreflex control of muscle sympathetic nerve activity and the heart rate in patients with essential hypertension.
Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension 1988 December
This study examined the effects of angiotensin II (Ang II) on blood pressure, heart rate and muscle sympathetic nerve activity in patients with essential hypertension and normotensive subjects. Muscle sympathetic nerve activity was measured by a microneurographic method. Graded doses of phenylephrine (0.5 and 1.0 g/kg per min) or Ang II (5, 10 and 20 ng/kg per min) were intravenously infused into supine subjects for 10 min at 30-min intervals. Although the pressor responses to Ang II and phenylephrine were enhanced in the hypertensives compared with the normotensives (both P less than 0.05), the reduction in muscle sympathetic nerve activity during infusion of phenylephrine and Ang II and the reduction in the heart rate during infusion of phenylephrine were significantly smaller in the hypertensives than in the normotensives. The decrease in the heart rate in response to Ang II was not significant in either group. Furthermore, in the two groups, the decreases in muscle sympathetic nerve activity and the heart rate were significantly smaller during infusion of Ang II than during infusion of phenylephrine. These results suggest that angiotensin II impairs the baroreflex function in patients with essential hypertension and in normotensive subjects, and that the blunted response of sympathetic nerve activity and the heart rate observed in the hypertensives may underlie the maintenance of high blood pressure.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app