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Formaldehyde Reacts with Amino Acids and Peptides with a Potential Role in Acute Methanol Intoxication.
Journal of Analytical Toxicology 2020 April 29
Methanol, an aliphatic alcohol widely used in the industry, causes acute and chronic intoxications associated with severe long-term health damage, including permanent visual impairment, brain damage, mainly necrosis of the basal ganglia, and high mortality due to cancer. However, the role of formaldehyde, an intermediate metabolite of methanol oxidation, in methanol toxicity remains unclear. Thus, we studied the reactivity of several amino acids and peptides in the presence of formaldehyde by identifying products by direct infusion electrospray high resolution mass spectrometry and matrix-assisted laser desorption-ionization mass spectrometry. Cysteine, homocysteine, and two peptides, CG and CGAG, provided cyclic products with a + 12 amu mass shift with respect to the original compounds. The proposed structures of the products were confirmed by high resolution tandem MS. Moreover, the formation of the products with +12 amu mass shift was also shown for two biologically relevant peptides, fragments of ipilimumab, which is a human IgG1 monoclonal antibody against cytotoxic T-lymphocyte-associated protein 4. Overall, our experimental results indicate that formaldehyde reacts with some amino acids and peptides, yielding covalently modified structures. Such chemical modifications may induce undesirable changes in the properties and function of vital biomolecules (e.g., hormones, enzymes) and consequently pathogenesis.
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