Juvenile Nasal Angiofibroma on 68 Ga-DOTANOC PET/CT: Exploring Theranostic Avenues

Pirabu Sakthivel, Alok Thakar, Arun Prashanth, Rakesh Kumar, Suresh Chandra Sharma, Rakesh Kumar
Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India 2020, 35 (2): 176-177
Somatostatin (SST) cell surface receptors (SSTRs) are expressed in many different malignant, benign, and neuroendocrine tumors. SSTRs are also expressed in the endothelium of human vessels during angiogenesis and not in the nonproliferating vessels. We present a case of 19-year-old boy with juvenile nasal angiofibroma (JNA), who underwent 68 Ga-DOTANOC PET/CT to explore SSTRs expression and theranostic potential. The scan revealed high uptake in the tumor, and in certain areas, the uptake was similar to that of the pituitary gland. Performance of DOTANOC PET/CT in JNA opens up new frontiers with respect to radiological staging, early recurrence identification, better delineation from postoperative scar tissue, possible preoperative treatment with SST analogs, and perhaps even radiopharmaceutical based-ligand therapy of inoperable/residual/recurrent JNAs in the future.

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