[The rs4705342 gene mutation in the promoter region of the miR-143/ 145 cluster associated with the risk of prostate cancer in the Chinese Han population].

Objective: To explore the correlation between the rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster and the risk of PCa in the Chinese Han population.

METHODS: We enrolled in this study 156 cases of PCa and 188 cancer-free controls. Using TaqMan SNP genotyping assay, we detected the polymorphism of rs4705342 in the promoter region of the miR-143/ miR-145 gene, and performed a stratified analysis on the family history of cancer, body mass index (BMI), age, smoking status, and alcohol consumption of the subjects.

RESULTS: The proportion of family history of cancer was significantly higher in the case group than in the control (P = 0.01). No statistically significant differences, however, were found between the two groups in age (P = 0.32), BMI (P = 0.79), smoking status (P = 0.47), and alcohol consumption (P = 0.34), nor in the distribution of the TT, CT and CC genotypes (P = 0.07) except in that of the CC and TT/CT combined genotypes (P = 0.01). There were statistically significant differences in the distribution of CC and TT/CT combined genotypes between the non-smoking subgroups, (P = 0.02) and alcohol drinking subgroups (P = 0.03), but not between the clinical stages of PCa (P = 0.81) or the levels of PSA (P = 0.39).

CONCLUSIONS: The rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster is significantly associated with the pathogenesis of PCa in the Chinese Han population.