We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Modified volumetric capnography-derived parameter: A potentially stable indicator in monitoring cardiopulmonary resuscitation efficacy in a porcine model.
Resuscitation 2020 May
AIM: We aimed to investigate whether the ability of the volumetric capnography-derived parameter, the volume of CO2 eliminated per minute and per kg body weight (V'CO2 kg-1 ), in monitoring the quality of CPR and predicting the return of spontaneous circulation (ROSC) remains undisturbed by hyperventilation.
METHODS: This randomised crossover study included 12 male domestic pigs. After 4 min of untreated ventricular fibrillation, mechanical CPR was administered. Following 5-min washout periods, each animal underwent two sessions of experiments; four 5-min ventilation trials followed by advanced life support, consecutively in the two sessions.
RESULTS: Different ventilation types had no significant impact on V'CO2 kg-1 or haemodynamics. However, PETCO2 was significantly affected by the ventilation type and coronary perfusion pressure (P < 0.05). The means ± standard deviations of PETCO2 decreased linearly with an increase in the respiratory rate (RR) (P < 0.05). The PETCO2 decreased from 20.42 ± 9.51 to 16.16 ± 5.07 (P < 0.05) as the tidal volume increased from 10 to 20 mL min-1 . No significant differences in V'CO2 kg-1 were observed between the three RR levels of ventilation types (P = 0.274). Post hoc analysis demonstrated a significant difference between the highest value of V'CO2 kg-1 in double tidal volume hyperventilation and normal ventilation and triple respiratory rate hyperventilation (P < 0.05). The AUC for V'CO2 kg-1 and PETCO2 in discriminating between survivors and non-survivors was 0.80 and 0.71, respectively.
CONCLUSIONS: V'CO2 kg-1 performs better than PETCO2 in monitoring the quality of CPR during hyperventilation. In predicting ROSC during variations in a ventilation state, V'CO2 kg-1 has good predictive ability.
METHODS: This randomised crossover study included 12 male domestic pigs. After 4 min of untreated ventricular fibrillation, mechanical CPR was administered. Following 5-min washout periods, each animal underwent two sessions of experiments; four 5-min ventilation trials followed by advanced life support, consecutively in the two sessions.
RESULTS: Different ventilation types had no significant impact on V'CO2 kg-1 or haemodynamics. However, PETCO2 was significantly affected by the ventilation type and coronary perfusion pressure (P < 0.05). The means ± standard deviations of PETCO2 decreased linearly with an increase in the respiratory rate (RR) (P < 0.05). The PETCO2 decreased from 20.42 ± 9.51 to 16.16 ± 5.07 (P < 0.05) as the tidal volume increased from 10 to 20 mL min-1 . No significant differences in V'CO2 kg-1 were observed between the three RR levels of ventilation types (P = 0.274). Post hoc analysis demonstrated a significant difference between the highest value of V'CO2 kg-1 in double tidal volume hyperventilation and normal ventilation and triple respiratory rate hyperventilation (P < 0.05). The AUC for V'CO2 kg-1 and PETCO2 in discriminating between survivors and non-survivors was 0.80 and 0.71, respectively.
CONCLUSIONS: V'CO2 kg-1 performs better than PETCO2 in monitoring the quality of CPR during hyperventilation. In predicting ROSC during variations in a ventilation state, V'CO2 kg-1 has good predictive ability.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app